RUB » Department of Biophysics » X-ray structure analysis of proteins

Protein Crystallography Group

Professor Dr. Eckhard Hofmann

Welcome to the Protein Crystallography Group.
We seek to determine the structure and functional mechanism of proteins. We use X-ray crystallography to determine the three-dimensional structures of those proteins in order to get insight into their function. The use of further biochemical and biophysical methods are crucial. A major focus in the laboratory is to understand the mechanism of membrane proteins.


News: PEBB structure from Johannes is accepted at JBC!

After long work Johannes succeeded in crystallizing PebB from the cryptophyte Guillardia theta and solving the structure. The complex with the natural substrate biliverdin was particularly revealing: The substrate does not bind in the orientation typical for the enzyme family, but rotated by 180°, which provides information about the function of the enzyme! The reviewers also found this exciting enough for JBC!

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